Read all of this leaflet carefully before you start using this medicine.

Keep this leaflet. You may need to read it again. If you have any further questions, after reading it, please ask your doctor or your pharmacist.

This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Do not use DuoTrav

• if you are allergic to travoprost, prostaglandins, timolol, beta-blockers or any of the other ingredients.
• if you have respiratory problems such as asthma, bronchitis or other types of breathing problems
• if you have severe hay fever
• if you have a slow heart beat, heart failure or disorders of heart rhythm
• If the surface of your eye is cloudy

Ask your doctor for advice if any of these apply to you.

Take special care

• DuoTrav may cause breathlessness or wheezing. If you are concerned about changes in your breathing pattern when using DuoTrav, tell your doctor as soon as possible.
• If you get any severe allergic reaction while you are using DuoTrav , whatever the cause, adrenaline treatment may not be as effective. So when receiving any other treatment please tell the health professional that you are taking DuoTrav.
• If you have angina, circulation problems or low blood pressure. DuoTrav may make any of these worse. If you are concerned about any changes in these symptoms, tell your doctor as soon as possible.
• If you have diabetes. DuoTrav can mask the symptoms of low blood sugar (hypoglycaemia) such as shakiness and dizziness, so you need to use it with care.
• If you are under 18. DuoTrav is not to be used by people under 18 years of age.
• DuoTrav may change the colour of your iris (the coloured part of your eye). This change may be permanent.
• DuoTrav may increase the length, thickness, colour and/or number of your eyelashes and may cause unusual hair growth on your eyelids.

Using other medicines

DuoTrav can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor if you are using or intend to take medicines to lower blood pressure, heart medicine or medicines to treat diabetes. Remember to mention also medicines that you obtained without prescription, over the counter.

 

Pregnancy and breast-feeding

Don't use DuoTrav if you are pregnant. If you could get pregnant you must use adequate contraception whilst you use the medicine.

If you are breast-feeding, DuoTrav may get into your milk .

Ask your doctor for advice before taking any medicine.

Driving and using machines

You may find that your vision is blurred for a time just after you use DuoTrav. Do not drive or use machines until this has worn off.

Important information about some of the ingredients

• If you wear soft contact lenses. Don't use the drops with your lenses in. Wait 15 minutes after using the drops before putting your lenses back in. There is a preservative in DuoTrav (benzalkonium chloride) that can discolour soft lenses.
• DuoTrav contains hydrogenated castor oil, which may cause skin reactions.

The usual dose

Adults: 1 drop in the eye or eyes, once a day - in the morning or in the evening. Use at the same time each day.

Only use DuoTrav in both eyes if your doctor told you to. Take it for as long as your doctor told you to.

Only use DuoTrav for dropping in your eyes.

• Immediately before using a bottle for the first time, tear-off the overwrap pouch take it out (picture 1) and write the date of opening on the label in the space provided
• Get the DuoTrav bottle and a mirror
• Wash your hands
• Twist off the cap
• Hold the bottle, pointing down, between your thumb and fingers
• Tilt your head back. Pull down your eyelid with a clean finger, until there is a 'pocket' between the eyelid and your eye. The drop will go in here (picture 2)
• Bring the bottle tip close to the eye. Use the mirror if it helps
• Don't touch your eye or eyelid, surrounding areas or other surfaces with the dropper. It could infect the drops
• Gently squeeze the bottle to release one drop of DuoTrav at a time (picture 3)
• After using DuoTrav, press a finger into the corner of your eye, by the nose (picture 4). This helps to stop DuoTrav getting into the rest of the body
• If you use drops in both eyes, repeat the steps for your other eye
• Close the bottle cap firmly immediately after use
• Only use one bottle at a time. Do not open the pouch until you need to use the bottle.

Turn the page for more advice

How much to use

< see side 1

If a drop misses your eye, try again.

If you use more DuoTrav than you should, rinse it all out with warm water. Don't put in any more drops until it's time for your next regular dose.

If you forget to use DuoTrav, continue with the next dose as planned. Do not use a double dose to make up. The dose should not exceed one drop in the affected eye(s) daily.

If you stop using DuoTrav without speaking to your doctor the pressure in your eye will not be controlled which could lead to loss of sight.

If you are using other eye drops, leave at least 5 minutes between putting in DuoTrav and the other drops.

If you have any other questions about your medicine, ask a doctor or pharmacist.

Very common side effects

This may affect up to 15 in every 100 people.

eye irritation, redness of the eye

Common side effects

One or more of these may affect up to 10 in every 100 people.

Effects in the eye: inflammation inside the eye, eye pain and swelling, sensitivity to light, conjunctival bleeding, blurred vision, dry eye, itchy eye, eye allergy, increased tear production, eyelid irritation, itching, redness, pain and swelling; tired eyes, increased growth or number of eye lashes

Effects in the body: nervousness, dizziness, headache, irregular or decreased heart rate, increased or decreased blood pressure, shortness of breath, hives, skin darkening around eyes, pain in hands and feet

Uncommon side effects

One or more of these may affect up to 1 in every 100 people

Effects in the eye: swollen conjunctiva

Effects in the body: cough, throat irritation, drip at back of throat, abnormal liver blood tests, skin inflammation and itching, coloured urine, thirst

Additional side effects that have been reported previously in people using eye drops containing travoprost or timolol and that have not been reported with DuoTrav include:

Effects in the eye: double vision, eyelid crusting, droopy eyelid, changes in the colour of the iris

Effects in the body: heart attack, heart failure, chest pain, stroke, decreased blood flow to the brain, fainting, low blood sugar, depression, generalised weakness, numbness or tingling sensation, diarrhoea, nausea, peeling skin, rash, stuffy nose, loss of hair

If any of the side effects gets serious or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

What DuoTrav contains

The active substances are travoprost 40 micrograms/ml and timolol 5 mg/ml.

Other ingredients: Benzalkonium chloride, mannitol, trometamol, polyoxyethylene hydrogenated castor oil 40 (HCO-40), boric acid, disodium edetate, hydrochloric acid (to adjust pH), purified water. Tiny amounts of hydrochloric acid are added to keep acidity levels (pH levels) normal.

What DuoTrav looks like and the contents of the pack

DuoTrav is a liquid (a clear, colourless solution) supplied in a pack containing a 2.5 ml plastic bottle with a screw cap or in a pack containing three or six 2.5 ml plastic bottles with screw caps. Each bottle is placed in a pouch. Not all pack sizes may be marketed.