INFORMATION FOR PATIENTS
Please read
this leaflet carefully before you are given this
medicine. It gives an outline of the more important
things you should know. If you want to know more about
this medicine, or if you are not sure about anything,
ask your doctor or nurse. You should keep this leaflet
whilst receiving treatment.
THE NAME
OF YOUR MEDICINE IS HYALASE (HYALURONIDASE)
The active
ingredient in HyalaseŽ is hyaluronidase
HyalaseŽ is
a sterile, freeze-dried powder in a 1ml neutral glass
ampoule, containing 1500 international units of the
active ingredient.
The
registered pack size is 10 x 1ml glass ampoules.
HOW DOES
YOUR MEDICINE WORK?
HyalaseŽ is
an enzyme, a natural substance that activates processes
in the body.
WHAT IS
HYALASEŽ FOR?
HyalaseŽ is
used to temporarily break down the natural barriers in
the body tissues so that injections or fluids injected
under the skin or into muscle are more easily spread and
absorbed.
HyalaseŽ is
also used to enable excess fluids and blood in the
tissues to be more easily reabsorbed.
BEFORE
ADMINISTRATION OF THIS MEDICINE
You should
not be given HyalaseŽ
- if
you are known to be allergic to the active
ingredient
- to
reduce the swelling of bites or stings
- at
sites where infection or malignancy is present
-
directly onto the front of the eye
- if
you are in premature labour for which there is no
explanation
You should
let your doctor know if you are pregnant, wish to become
pregnant, or are breast-feeding before HyalaseŽ is
administered.
HyalaseŽ
should not be administered by intravenous injection.
If you have
any doubts about whether this medicine should be
administered then talk to your doctor or nurse before it
is given to you.
ADMINISTERING THIS MEDICINE
The usual
dose for HyalaseŽ is 1500iu. Hyaluronidase for injection
is dissolved in water for injections, normal saline or
the solution to be injected. Your doctor or nurse will
give the injection either into a muscle (intramuscular)
or under the skin (subcutaneous). For subcutaneous
infusion (an injection given continuously under the
skin), the injection is injected into the infusion
tubing.
Your doctor
will decide the dose and route of administration that is
best for you. If you do not understand what you are
being given, or are in any doubt, ask your doctor or
nurse.
ARE
THERE ANY SIDE-EFFECTS?
Like many
medicines HyalaseŽ may cause side-effects in some
patients. HyalaseŽ has on rare occasions caused allergic
reactions (rash, itching, swelling around the eyes) or
soreness, bleeding or bruising at the injection site.
Very rarely, severe allergic reactions to Hyalase may
occur, with difficulty breathing, rapid pulse and
profuse sweating. If you develop any of these symptoms,
contact your doctor or nurse immediately.
Local
swelling may occur when HyalaseŽ is used with
subcutaneous infusions.
If you
experience any side-effects or feel that the medicine is
affecting you badly tell your doctor or nurse
immediately.
SAFE
KEEPING FOR YOUR MEDICINE
- This
medicine should not be used if the expiry date on
the label has passed or if the powder shows signs of
discoloration.
- The
injection must be used immediately after
preparation. Any portion of the contents not used at
once should be discarded.
- The
ampoule should not be stored above 25°C. Keep the
ampoule tightly closed.
-
Store the ampoule in the package or container in
which it was dispensed.
- Keep
this medicine in a secure place where children
cannot get at it.
-
Dispose of all used ampoules and syringes carefully.
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